化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl butylmalonate → Phytanic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl butylmalonate | HCID 67244 | — |
| 反応物 | Diethyl 2-benzylpropanedioate | HCID 69090 | — |
| 反応物 | Decanoic acid, 2-methyl- | HCID 91167 | — |
| 反応物 | Phytol | HCID 5280435 | — |
| 反応物 | 2-Butyldodecanoic acid | HCID 12424127 | — |
| 反応物 | 2,2-Dibutyldodecanoic acid | HCID 19087895 | — |
| 触媒 | chromium (VI) trioxide | HCID 10219390 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Phytanic Acid | HCID 26840 | — |
反応手順
The 2-benzylalkanoic and 2-butylalkanoic acids were prepared by the malonic ester method starting from diethyl benzylmalonate or diethyl butylmalonate and the appropriate alkyl bromide. The procedure used was analogous to that for the preparation of 2-methyldecanoic acid. Preparation of 2,2-dibutyldodecanoic acid was accomplished by alkylation of 2-butyldodecanoic acid using the method of Pfeffer, Silbert, and Chirinko. Hydrogenation of phytol followed by oxidation of the resulting saturated alcohol with a solution of chromium trioxide in acetic acid gave 3,7,11,15-tetramethylhexadecanoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04556495 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-7c1a0b002e334083948a27da8d74ec1b |
| 出典メモ | uspto-grants-1985_12 |