Benzyl acrylate → HCID 10984057、化合物

HRID 637296

反応式

HRID 637296 の反応式
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:21])=[C:11]([N:15]4[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]4)[C:12]=3[F:14])[C:7](=[O:22])[C:6]([C:23]([OH:25])=[O:24])=[CH:5]2)[CH2:3][CH2:2]1.[C:26]([O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(=[O:29])[CH:27]=[CH2:28]>>[CH2:31]([O:30][C:26]([CH2:27][CH2:28][N:18]1[CH2:17][CH2:16][N:15]([C:11]2[C:12]([F:14])=[C:13]3[C:8]([C:7](=[O:22])[C:6]([C:23]([OH:25])=[O:24])=[CH:5][N:4]3[CH:1]3[CH2:2][CH2:3]3)=[CH:9][C:10]=2[F:21])[CH2:20][CH2:19]1)=[O:29])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

参加物

3

反応物 2

HCID 75617Benzyl acrylateHCID 1228488-Fluorociprofloxacin

生成物 1

HCID 10984057HCID 10984057、化合物収率 45%

実験手順

3.5 g (0.01 mol) of 1-cyclopropyl-6,8-difluoro-7-(piperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid are heated under reflux with 4 g of benzyl acrylate for 5 hours. The hot solution is filtered, and the precipitate which separates out is filtered off under suction, washed with ethanol and dried. 2.3 g of 7-[4-(2-benzyloxycarbonyl-ethyl)-piperazin-1-yl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid having a decomposition temperature of 132°-135° C. are obtained.

後処理

  1. filtrationThe hot solution is filtered
  2. filtrationthe precipitate which separates out is filtered off under suction
  3. washwashed with ethanol
  4. customdried

出典と根拠

ORDレコード
ord-cadaf296b38f4444a0bed791361890a1
出典データセット
uspto-grants-1985_12
特許番号
US04556658

関連ノート

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