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Diisopropylamine → 1-(4-Bromobutyl)cyclopentanecarboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | 1,4-Dibromobutane | HCID 8056 | — |
| 反応物 | Methyl cyclopentanecarboxylate | HCID 78365 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 1-(4-Bromobutyl)cyclopentanecarboxylic acid methyl ester | HCID 22954343 | — |
反応手順
The title compound was prepared using a similar procedure as described in Example 1, Step 1, starting from diisopropylamine (21 mL, 150 mmol), n-butyllithium (58 mL, 145 mmol), cyclopentanecarboxylic acid methyl ester (13.1 g, 100 mmol), and 1,4-dibromobutane (21.59 g, 100 mmol), and after distillation, resulted in a colorless oil (12.8 g, 48%). ES(+)-HRMS m/e calcd. for C11H19BrO2 (M+H)+ 262.0568, obsd. 262.0565.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447035B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-08af6405ee1145fda3d257da68d88168 |
| 出典メモ | uspto-grants-2016_09 |