化工社化工社 化学情報印刷レポート · 研究参考用
Ganciclovir → Ganciclovir Di-O-acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ganciclovir | HCID 135398740 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | Ganciclovir Di-O-acetate | HCID 135459822 | 181.5% |
反応手順
A mixture of 3.00 g of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, 300 mg of 4-dimethylaminopyridine, and 100 ml of acetic anhydride was vigorously stirred for 3 days at room temperature. The acetic anhydride was removed by evaporation at reduced pressure and the residue recrystallized from methanol to give 3.62 g of 9-(1,3-diacetyloxy-2-propoxymethyl)guanine, m.p. 237°-239° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04556659 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-6cc821f002e64baa9db9fa54e995b5fd |
| 出典メモ | uspto-grants-1985_12 |