Hydrochloric Acid → 2-(2-Ureidophenyl)acetic acid

HRID 637358ノート

反応式

HRID 637358 の反応式
C1(C([NH:9][C:10]([N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C:13]2=[O:21])=[O:11])=O)CCCCC1.Cl.[OH-:23].[K+]>>[NH:12]([C:20]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:14][C:13]([OH:21])=[O:23])[C:10]([NH2:9])=[O:11]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13647650N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

生成物 1

HCID 136476542-(2-Ureidophenyl)acetic acid

実験手順

A slurry of 2.9 g (0.01 mole) of N-cyclohexylcarbonyl-2-oxindole-1-carboxamide in 50 ml of 1N potassium hydroxide solution was stirred at room temperature for ca. 30 minutes, during which time the solid went into solution. At this point, the reaction mixture was acidified with concentrated hydrochloric acid, with ice cooling, and then it was extracted with ethyl acetate. The extracts were washed with saturated sodium chloride solution, dried (Na2SO4) and evaporated in vacuo to give an oily solid. The oily solid was washed with diisopropyl ether and then it was recrystallized from ethanol to give 70 mg of the title compound, m.p. 174.5° C. (dec.).

後処理

  1. extractionit was extracted with ethyl acetate
  2. washThe extracts were washed with saturated sodium chloride solution
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo
  5. customto give an oily solid
  6. washThe oily solid was washed with diisopropyl ether
  7. customit was recrystallized from ethanol

出典と根拠

ORDレコード
ord-b4b20e9e890c4e5fbb8aadcd9a821438
出典データセット
uspto-grants-1985_12
特許番号
US04556672

反応ノート

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