Oxindole → N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

HRID 637360ノート

反応式

HRID 637360 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]1([C:17]([N:19]=[C:20]=[O:21])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[CH:11]1([C:17]([NH:19][C:20]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][C:2]2=[O:10])=[O:21])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 321710OxindoleHCID 20096062Cyclohexanecarbonyl isocyanate

生成物 1

HCID 13647650N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred slurry of 20.0 g (0.15 mole) of 2-oxindole in 150 ml of toluene was added 29.6 g (0.19 mole) of cyclohexylcarbonyl isocyanate. The mixture was heated under reflux for ca. 30 minutes and then it was cooled to room temperature. The solid was recovered by filtration and then it was recrystallized from ethanol. This afforded 26.5 g of the title compound as fluffy, colorless crystals, m.p. 144.5°-145.5° C.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for ca. 30 minutes
  3. filtrationThe solid was recovered by filtration
  4. customit was recrystallized from ethanol

出典と根拠

ORDレコード
ord-893367bcce604dbfb9515c860ba36956
出典データセット
uspto-grants-1985_12
特許番号
US04556672

反応ノート

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