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Hydrochloric Acid → 2-cyclopentyl-1-[p-(N,N-dimethyl-2-aminoethoxy)phenyl]-1-(p-hydroxyphenyl)-1-butanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (2-(4-Bromophenoxy)ethyl)dimethylamine | HCID 213877 | — |
| 反応物 | alpha-Cyclopentyl-p-hydroxybutyrophenone | HCID 13175265 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-cyclopentyl-1-[p-(N,N-dimethyl-2-aminoethoxy)phenyl]-1-(p-hydroxyphenyl)-1-butanol | HCID 20256938 | — |
反応手順
2-cyclopentyl-1-[p-(N,N-dimethyl-2-aminoethoxy)phenyl]-1-(p-hydroxyphenyl)-1-butanol, which was prepared from α-cyclopentyl-p-hydroxybutyrophenone and p-(N,N-dimethyl-2-aminoethoxy) bromobenzene according to the procedure of example 3, was dehydrated in ethanol in the presence of hydrochloric acid. The product was recrystallized from n-hexane, mp. 112°-120° C. and was found to be an 1:1 mixture of E- and Z-isomers.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04556677 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-4fcd5461932b4ca9abf4342ca40471a3 |
| 出典メモ | uspto-grants-1985_12 |