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Ethanol → 1-(Benzyloxyphenyl)-3-(3-pyridyl)-2-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(3-(Phenylmethoxy)phenyl)ethan-1-one | HCID 98689 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(Benzyloxyphenyl)-3-(3-pyridyl)-2-propen-1-one | HCID 3649663 | — |
反応手順
To a solution of NaOH (0.488 g) in 10 ml of H2O was added 5 ml of 95% ethanol, followed by 3-benzyloxyacetophenone (2.5 g). The resulting solution was cooled to 0°-5° C. and pyridine-3-carbaldehyde (0.903 ml) added. After standing at 0°-5° C. for 18 hours, present title product was recovered by filtration and purified by chromatography on silica gel using 1:4 ethyl acetate:CH2Cl2 as eluant to yield 1.5 g of purified title product as an off-white solid; mp 117°-119° C.; IR (KBr) 1660 cm-1;Anal. C 79.83, H 5.50, N 4.22, calcd. C 79.98, H 5.43, N 4.44.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248685 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-b5deb4b9277448c289c6682e2181b440 |
| 出典メモ | uspto-grants-1993_09 |