Potassium Carbonate → (S)-2-[4-(3-tert-butoxycarbonylaminopropoxy)-2,6-dichlorobenzoylamino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester

関与物質

反応手順

The title compound was prepared using a similar procedure as described in Example 5, Step 5, starting from (S)-2-(2,6-dichloro-4-hydroxy-benzoylamino)-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester (558 mg, 1.07 mmol), 3-tert-butoxycarbonylaminopropyl bromide (306 mg, 1.28 mmol), and potassium carbonate (445 mg, 3.22 mmol), and after ISCO column chromatography purification, resulted in a white solid (654 mg, 87%). ES(+)-HRMS m/e calcd. for C34H42Cl2N4O8 (M+H)+ 705.2453, obsd. 705.2451.

情報源と証拠