化工社化工社 化学情報印刷レポート · 研究参考用
5-Nitrobenzofuran-2-carboxylic acid → Ethyl 5-aminobenzofuran-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Nitrobenzofuran-2-carboxylic acid | HCID 1477128 | — |
| 反応物 | Ethyl 5-amino-1-benzothiophene-2-carboxylate | HCID 2764450 | — |
| 生成物 | Ethyl 5-aminobenzofuran-2-carboxylate | HCID 9837138 | — |
反応手順
The appropriate arylcarboxylic acid is synthesized by the coupling of indole-2-carboxylic acid, benzofuran-2-carboxylic acid or benzothiophene-2-carboxylic acid with ethyl 5-amino-aryl-2-carboxylate in DMF with EDCI, and saponification of the ester. Ethyl 5-aminoindole-2-carboxylate is formed by catalytic hydrogenation of ethyl 5-nitroindole-2-carboxylate (Parmerter, S. M.; Cook, A. G.; Dixon, W. B. J. Am. Chem. Soc. 1958, 80, 4621). Ethyl 5-aminobenzothiophene-2-carboxylate can be synthesized as described in: Zambias, R. A.; Hammond, M. L. J. Syn. Commun. 1991, 21, 959. Ethyl 5-aminobenzofuran-2-carboxylate is prepared from the commercially available 5-nitrobenzofuran-2-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248691 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-cb967cd9eaa84622bff0d06681a8f931 |
| 出典メモ | uspto-grants-1993_09 |