Sodium Cyanide → 2-(2-Fluorophenyl)propanenitrile

HRID 637613ノート

反応式

HRID 637613 の反応式
[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7](Cl)[CH3:8]>CS(C)=O>[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7]([C:1]#[N:2])[CH3:8]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 135643251-(1-Chloroethyl)-2-fluorobenzene

生成物 1

HCID 133880122-(2-Fluorophenyl)propanenitrile収率 85.1%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
90 °C

実験手順

In 300 ml of dimethyl sulfoxide was dissolved 35 g of sodium cyanide by heating at 90° C., and 45 g of 2-fluoro-α-methylbenzyl chloride was added. The mixture was stirred at 90° C. for 4 hours, and then cooled. Ice-water was added and the mixture was extracted with n-hexane. The n-hexane layer was washed with water and dried over anhydrous magnesium sulfate and the solvent was evaporated off. The residue obtained was purified by distillation under reduced pressure to afford 36 g of 2-fluoro-α-methylbenzyl cyanide, b.p.0.5 55° C.

後処理

  1. temperaturecooled
  2. extractionthe mixture was extracted with n-hexane
  3. washThe n-hexane layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated off
  6. customThe residue obtained
  7. distillationwas purified by distillation under reduced pressure

出典と根拠

ORDレコード
ord-b4950e3dd7e146fd8c32b508fa2be13f
出典データセット
uspto-grants-1985_12
特許番号
US04557871

反応ノート

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