17beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3-one → 17beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3beta-ol

HRID 637646

反応式

HRID 637646 の反応式
[C:1]([O:4][C@@:5]1([CH2:26][CH2:27][CH3:28])[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:21]([CH2:22][CH2:23][C@:6]12[CH3:7])[C@:19]1([CH3:20])[C@H:14]([CH2:15][C:16](=[O:25])[CH2:17][C@@H:18]1[CH3:24])[CH2:13][CH2:12]3)(=[O:3])[CH3:2].[H-].C(O[Al](OC(C)(C)C)OC(C)(C)C)(C)(C)C.[Li+]>>[C:1]([O:4][C@@:5]1([CH2:26][CH2:27][CH3:28])[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:21]([CH2:22][CH2:23][C@:6]12[CH3:7])[C@:19]1([CH3:20])[C@H:14]([CH2:15][C@@H:16]([OH:25])[CH2:17][C@@H:18]1[CH3:24])[CH2:13][CH2:12]3)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 1302088617beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3-oneHCID 16710494Lithium tri-tert-butoxyaluminohydride

生成物 1

HCID 7036026117beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3beta-ol収率 64.7%

実験手順

1.0 g of 17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3-one is reacted as described in Example 6 with lithium tri-tert.-butoxyaluminum hydride and worked up. After chromatography on silica gel, 650 mg of 17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3β-ol is obtained as an oil.

出典と根拠

ORDレコード
ord-c57fb37166684883a243a0c987bdbe6f
出典データセット
uspto-grants-1985_12
特許番号
US04558041

関連ノート

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