Methylamine → 5-Thiazolecarboxamide, N,4-dimethyl-2-(4-methoxyphenyl)-

HRID 637711

反応式

HRID 637711 の反応式
[CH3:1][NH2:2].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][C:13]([C:17]([O:19]CC)=O)=[C:14]([CH3:16])[N:15]=2)=[CH:7][CH:6]=1>C(O)C>[CH3:16][C:14]1[N:15]=[C:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][CH3:3])=[CH:6][CH:7]=2)[S:12][C:13]=1[C:17]([NH:2][CH3:1])=[O:19]

参加物

4

反応物 2

HCID 6329MethylamineHCID 7540952Ethyl 2-(4-methoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

生成物 1

HCID 30680765-Thiazolecarboxamide, N,4-dimethyl-2-(4-methoxyphenyl)-収率 69%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into a mixed solvent of 80 ml of 40% methylamine and 600 ml of ethanol, 13.9 g of ethyl 2-(4-methoxyphenyl)-4-methylthiazole-5-carboxylate was dissolved. Then, in a similar manner as in Example 1, the object was obtained as colourless minute aciculate melting at 157.5° to 159° C. in an amount of 9.1 g corresponding to the yield of 69%.

後処理

  1. customThen, in a similar manner as in Example 1, the object was obtained as colourless minute aciculate melting at 157.5° to 159° C. in an amount of 9.1 g corresponding to the yield of 69%

出典と根拠

ORDレコード
ord-32fcbd1c17634c8d955f3fb3536b1d48
出典データセット
uspto-grants-1985_12
特許番号
US04558059

関連ノート

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