関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Aluminum Stearate | HCID 12496 | — |
| 反応物 | Apraclonidine dihydrochloride | HCID 21479682 | — |
| 生成物 | Apraclonidine | HCID 2216 | — |
反応手順
The aluminum stearate was dispersed with stirring in a portion of the sunflower oil heated to 115° C. The dispersion was added to the rest of the sunflower oil heated to 140° C. The gel was stirred at 130° C. for 15 minutes and then allowed to cool without stirring to room temperature. The milled p-Amino Clonidine dihydrochloride was dispersed in the cooled gel base and then passed through a colloid mill to produce a fine, homogenous dispersion. The dispersion was filled into plastic bottles fitted with a dosing pump.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04558063 |
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| 出典データセット | uspto-grants-1985_12 |
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| ORD ID | ord-c167cef229d340d2aba763d3cc9a83b8 |
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| 出典メモ | uspto-grants-1985_12 |
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