Dimethylformamide → Idebenone

HRID 637893

反応式

HRID 637893 の反応式
CN(C)[CH:3]=[O:4].[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:22]([OH:23])=[C:21]([O:24][CH3:25])[C:20]([O:26][CH3:27])=[CH:19][C:18]=1C>O=O>[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:22](=[O:23])[C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[C:3](=[O:4])[C:18]=1[CH3:19]

参加物

4

反応物 2

HCID 6228DimethylformamideHCID 128241262-(10-Hydroxydecyl)-5,6-dimethoxy-3-methylphenol

生成物 1

HCID 3686Idebenone

試薬・触媒・溶媒 1

HCID 977Oxygen溶媒

実験手順

To a dimethylformamide solution (50 ml) of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol (2.53 g) is added bis(salicylidene)ethylenediiminocobalt(II) (salcomine) (0.1 g) and the mixture is stirred in oxygen streams at atmospheric temperature and pressure for 72 hours. The solvent is then distilled off and the product is extracted with ether. The ethereal layer is washed with water and dried over anhydrous sodium sulfate, and the solvent is distilled off. The above procedure yields 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (2.32 g) as orange-yellow needles melting at 52° C.

後処理

  1. distillationThe solvent is then distilled off
  2. extractionthe product is extracted with ether
  3. washThe ethereal layer is washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationthe solvent is distilled off

出典と根拠

ORDレコード
ord-89389e2d066544e2a89c18db6e62ed8f
出典データセット
uspto-grants-1985_12
特許番号
US04559177

関連ノート

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