Water → 4,6-Dichloro-N-(2,3-dimethylphenyl)-1,3,5-triazin-2-amine

HRID 637929ノート

反応式

HRID 637929 の反応式
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=1[CH3:19]>CC(C)=O>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=2[CH3:19])[N:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 68932,3-DimethylanilineHCID 7954Cyanuric chloride

生成物 1

HCID 134137564,6-Dichloro-N-(2,3-dimethylphenyl)-1,3,5-triazin-2-amine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
5 °C

実験手順

A solution of cyanuryl chloride (18 g) in hot acetone (70 ml) is poured under stirring into water (40 ml). To the so obtained suspension is added, while keeping the temperature to 5° C., 2,3-xylidine (24 ml). Stirring is maintained for 1 hour at 5° C.; then the reaction mixture is filtered, the precipitate is washed with water to neutrality; it is dissolved in ethyl acetate; the solution is dried over Na2SO4. By concentration 16.8 g of the desired compound are obtained. M.p. 186°-188° C. (ethyl acetate/hexane).

後処理

  1. additionTo the so obtained suspension is added
  2. customto 5° C.
  3. filtrationthen the reaction mixture is filtered
  4. washthe precipitate is washed with water to neutrality
  5. dissolutionit is dissolved in ethyl acetate
  6. dry with materialthe solution is dried over Na2SO4

出典と根拠

ORDレコード
ord-3b8f1c2cb536492f82ada188fe6989ca
出典データセット
uspto-grants-1985_12
特許番号
US04559345

反応ノート

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