HCID 117988523、化合物 → 2-(3-(hydroxymethyl)phenyl)-N,N-dimethyl-4-morpholinopyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
反応式
N[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:11]3=[CH:20][C:21]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])=[CH:22][N:10]3[N:9]=2)=[CH:4][CH:3]=1.[OH:28][CH2:29]C1C=C(C2N=C(N3CCOCC3)C3=CC(C(O)=O)=CN3N=2)C=CC=1>>[OH:28][CH2:29][C:7]1[CH:6]=[C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:11]3=[CH:20][C:21]([C:23]([N:25]([CH3:26])[CH3:27])=[O:24])=[CH:22][N:10]3[N:9]=2)[CH:4]=[CH:3][CH:2]=1参加物
3
実験手順
Compound 18 was prepared by the method which was identical with that for preparing compound 12a, wherein compound 17 (92 mg, 0.26 mmol) was used as the starting material. White solid (80 mg, 80.8%). m.p. 170-171° C. 1H NMR (300 MHz, CDCl3): δ 8.22 (s, 1H), 8.20-8.17 (m, 1H), 7.84 (d, J=1.5 Hz, 1H), 7.46-7.43 (m, 2H), 7.04 (d, J=1.5 Hz, 1H), 4.77 (s, 2H), 4.11 (t, J=4.7 Hz, 4H), 3.87 (t, J=4.7 Hz, 4H), 3.20 (br, s, 6H). LC-MS: 382 (M+1).
出典と根拠
- ORDレコード
- ord-f43727d52c14457d84ba7dfbeaf4afc7
- 出典データセット
- uspto-grants-2016_09
- DOI