Dimethylformamide dimethyl acetal → 2(1H)-Pyridinone, 5-acetyl-6-[2-(dimethylamino)ethenyl]-
反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:11])[NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C=O>[C:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:11])[NH:8][C:9]=1[CH:10]=[CH:14][N:15]([CH3:17])[CH3:16])(=[O:3])[CH3:2]参加物
4
実験手順
A mixture containing 15.1 g of 5-acetyl-6-methyl-2(1H)-pyridinone, 200 ml of dimethylformamide and 15 ml of dimethylformamide dimethyl acetal was stirred at room temperature for 30 minutes, heated gently with stirring on a steam bath for 2 hours, then allowed to cool and stirred at room temperature overnight. The golden yellow needles that separated were collected, washed with methanol and dried in a vacuum oven at 80° C. to yield 10.7 g of 5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone, m.p. 238°-240° C.
後処理
- temperatureheated gently
- stirringwith stirring on a steam bath for 2 hours
- temperatureto cool
- stirringstirred at room temperature overnight
- customThe golden yellow needles that separated
- customwere collected
- washwashed with methanol
- customdried in a vacuum oven at 80° C.
出典と根拠
- ORDレコード
- ord-d30d02f7b4944228a3dfe38fa2c6f282
- 出典データセット
- uspto-grants-1985_12
- 特許番号
- US04559347
反応ノート
読み込み中…