Dimethylformamide dimethyl acetal → HCID 53841137、化合物

HRID 637963ノート

反応式

HRID 637963 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[O:11])[NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>CO>[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[O:11])[NH:8][C:9]=1[CH:10]=[CH:16][N:17]([CH3:19])[CH3:18])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27654765-Acetyl-2-hydroxy-6-methylnicotinonitrile

生成物 1

HCID 53841137HCID 53841137、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture containing 35.2 g of 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile, 300 ml of methanol and 30 ml of dimethylformamide dimethyl acetal was heated with stirring on a steam bath for 4 and 1/2 hours and then allowed to cool to room temperature. The precipitated yellow solid was collected, washed with methanol and dried in an oven under reduced pressure at 95° C. to yield 16.4 g of 5-acetyl-1,2-dihyro-6-(2-dimethylaminoethenyl)-2-oxo-3-pyridinecarbonitrile, m.p. 267°-270° C.

後処理

  1. temperaturewas heated
  2. customThe precipitated yellow solid was collected
  3. washwashed with methanol
  4. customdried in an oven under reduced pressure at 95° C.

出典と根拠

ORDレコード
ord-59f90878df024139aee310928892af94
出典データセット
uspto-grants-1985_12
特許番号
US04559347

反応ノート

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