関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Chlorobenzyl alcohol | HCID 28810 | — |
| 反応物 | Rolziracetam | HCID 71893 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-Oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester | HCID 15588872 | — |
反応手順
Five grams of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione (III) are dissolved in 31 g of o-chlorobenzyl alcohol and 0.2 ml of concentrated hydrochloric acid is added. The solution is heated at 100° C. for 71 hours. The mixture is cooled and dissolved in 150 ml of anhydrous diethylether. The solution is cooled to induce crystallization and the resulting crystals are isolated by filtration. Recrystallization from toluene-diethyl ether yields 5-oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester with a melting point of 99°-100° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04559358 |
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| 出典データセット | uspto-grants-1985_12 |
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| ORD ID | ord-d3fb22833c244b4f8cadb28ef832cbb2 |
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| 出典メモ | uspto-grants-1985_12 |
|---|
