化工社化工社 化学情報印刷レポート · 研究参考用
Hydroquinone → 3,4-Dihydro-2H-1-benzopyran-6-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroquinone | HCID 785 | — |
| 反応物 | Isophytol | HCID 10453 | — |
| 反応物 | Sodium Dithionite | HCID 24489 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 生成物 | 3,4-Dihydro-2H-1-benzopyran-6-ol | HCID 15122338 | — |
反応手順
2,6-dimethylquinone 111 is reduced with sodium dithionite to the hydroquinone 112, which is then reacted with 3,7,11,15-tetramethyl-3-hydroxy-1-hexadecene 113 and ZnCl2 to form the 6-chromanol 114. Conversion to the protected intermediate 115 is followed by bromination with Br2 and silver trifluoroacetate to form the bromide 116. Finally, 116 can be deprotected and oxidized with ceric ammonium nitrate (CAN) to yield 117.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447006B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-a4c73b0460b94898a0a84e03a3b86891 |
| 出典メモ | uspto-grants-2016_09 |