Epichlorohydrin → 1,5-Dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole

HRID 638066ノート

反応式

HRID 638066 の反応式
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][CH:4]=[C:3]1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:21]([CH:23]1[O:25][CH2:24]1)Cl>>[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][CH:4]=[C:3]1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:21][CH:23]2[O:25][CH2:24]2)[CH:9]=1

参加物

4

反応物 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 202551681,5-Dimethyl-2-(3-hydroxyphenyl)-pyrrole

生成物 1

HCID 202551361,5-Dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole

実験手順

While stirring, a mixture of 10 g of the resulting crude 1,5-dimethyl-2-(3-hydroxyphenyl)-pyrrole, 50 ml of epichlorohydrin and 15.2 g of potassium carbonate is heated at boiling point for 3 hours. The reaction mixture is cooled, filtered and concentrated by evaporation. The residue is divided between 200 ml of ether and 20 ml of 2N sodium hydroxide solution; the ether phase is separated off, dried over magnesium sulphate and concentrated by evaporation. The crude 1,5-dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole is obtained in the form of an oil and is further used in that form.

後処理

  1. temperatureis heated
  2. customfor 3 hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation
  6. customthe ether phase is separated off
  7. dry with materialdried over magnesium sulphate
  8. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-1ef0c8ba247b4bc3891994ddb290965c
出典データセット
uspto-grants-1985_12
特許番号
US04559354

反応ノート

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