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Dimethyl Sulfoxide → m-Trifluoromethylphenylacetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 3-(Trifluoromethyl)benzyl chloride | HCID 69716 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | m-Trifluoromethylphenylacetonitrile | HCID 75360 | 107.1% |
反応手順
A mixture of 12.0 g (61.5 mmole) m-trifluoromethylbenzyl chloride, 9.56 g (195 mmole) sodium cyanide and 60 ml dimethylsulfoxide was heated at 50° to 80° C. for four hours and poured into water. The aqueous mixture was extracted with methylene chloride, the extracts dried over sodium sulfate and the solvent evaporated in vacuo to give 12.2 g of yellow oil which was used in the next step. 1H-NMR(CDCl3)ppm(delta): 3.80 (s, 2H), 7.60 (s, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04560690 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-d46f14b90c1e453ea64887a24298fe1f |
| 出典メモ | uspto-grants-1985_12 |