Ethanol → N-Ethylisonicotinamide

HRID 638305

反応式

HRID 638305 の反応式
C(O)C.[CH2:4]([NH2:6])[CH3:5].[C:7](OC)(=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1>O>[CH2:4]([NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)[CH3:5]

参加物

5

反応物 3

HCID 702EthanolHCID 6341EthylamineHCID 227085Methyl isonicotinate

生成物 1

HCID 571600N-Ethylisonicotinamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 200 ml of ethanol and 20 ml water was cooled in an ice bath and saturated with ethylamine for 0.5 hr. then 80 g of crude methyl isonicotinate was added with cooling. Ethylamine was again bubbled onto the reaction mixture for 10 min and then it was allowed to stand overnight at room temperature. It was then concentrated in vacuo to leave 82.82 g of a pale oil which became semisolid on cooling.

後処理

  1. temperaturewith cooling
  2. customEthylamine was again bubbled onto the reaction mixture for 10 min
  3. concentrationIt was then concentrated in vacuo

出典と根拠

ORDレコード
ord-9cbaf1315d844d779728f10b59c9163a
出典データセット
uspto-grants-1985_12
特許番号
US04560692

関連ノート

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