Potassium Carbonate → HCID 53690852、化合物

HRID 638482

反応式

HRID 638482 の反応式
[N+:1]([C:4]1[CH:17]=[C:16]([C:18]([F:21])(F)F)[CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)([O-:3])=[O:2].Br[CH:23]([CH3:33])[C:24]([O:31][CH3:32])=[CH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[N+:1]([C:4]1[CH:17]=[C:16]([CH2:18][F:21])[CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH:23]([CH3:33])[C:24]([O:31][CH3:32])=[CH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:11][CH:12]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 233251014-[2-Nitro-4-(trifluoromethyl)phenoxy]phenolHCID 53787831Ethyl 4-bromo-3-methoxypent-2-enoate

生成物 1

HCID 53690852HCID 53690852、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4-(2-nitro-4-trifluoromethylphenoxy)phenol (9.36 mm), ethyl 4-bromo-3-methoxy-2-pentenoate (12 mm.) and K2CO3 (14 mm.) in acetone (20 ml.) is refluxed for 24 hours. After filtration, the filtrate is concentrated and the oily residue chromatographed on silica gel to yield ethyl 4-[4-(2-nitro-4-fluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoate.

後処理

  1. temperatureis refluxed for 24 hours
  2. filtrationAfter filtration
  3. concentrationthe filtrate is concentrated
  4. customthe oily residue chromatographed on silica gel

出典と根拠

ORDレコード
ord-38ee8d45f19e47d08476597e77d902e0
出典データセット
uspto-grants-1985_12
特許番号
US04561882

関連ノート

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