Acetyl chloride → HCID 20252442、化合物

HRID 638506ノート

反応式

HRID 638506 の反応式
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:25]=[CH:24][C:13]([O:14][CH:15]([CH3:23])[CH:16]([OH:22])[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[C:28](Cl)(=[O:30])[CH3:29].C(N(CC)CC)C>C(Cl)Cl>[F:27][C:2]([F:26])([F:1])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:25]=[CH:24][C:13]([O:14][CH:15]([CH3:23])[CH:16]([O:22][C:28](=[O:30])[CH3:29])[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)=[N:7][CH:8]=1

参加物

5

反応物 3

HCID 6367Acetyl chloride2 回HCID 8471Triethylamine2 回HCID 179796Methyl 3-hydroxy-4-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)valerate

生成物 1

HCID 20252442HCID 20252442、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5 g of methyl 4-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-hydroxypentanoate were dissolved in 35 ml of methylene chloride at 0° C. 0.9 ml of acetyl chloride and then 0.94 ml of triethylamine were added dropwise under nitrogen. After 18.5 hours of standing at room temperature and three hours of reflux, an additional 0.9 ml of acetyl chloride and 0.94 ml of triethylamine were added. The mixture was washed with water dilute acid and brine. The product was purified using silica gel chromatography and identified as the above methyl-3-acetoxy ester.

後処理

  1. temperatureof reflux
  2. washThe mixture was washed with water
  3. additiondilute acid and brine
  4. customThe product was purified

出典と根拠

ORDレコード
ord-64337e2d43dc400eac71e1f089bd78b8
出典データセット
uspto-grants-1985_12
特許番号
US04561882

反応ノート

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