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Pyridine → 2-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Hydrazide (H3N21-) | HCID 168365 | — |
| 反応物 | 2-Carbamoyl-3-quinolinecarboxylic acid | HCID 1534342 | — |
| 反応物 | Furo[3,4-b]quinoline-1,3-dione | HCID 4325463 | — |
| 生成物 | 2-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid | HCID 13474736 | — |
反応手順
The aminoamide (24.25 mmol) is added over a two hour period to a solution of 2,3-quinolinedicarboxylic anhydride (20.06 mmol) in pyridine (100 mL) while maintaining the reaction mixture at room temperature. The mixture is allowed to stir at room temperature for one-half hour. Analysis of the isomer distribution of the reaction products by high performance liquid chromatography shows an 8.9/1 ratio of the desired 2-carbamoyl-3-quinolinecarboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04562257 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-526a40f85ffe40aaa4af8111792f6707 |
| 出典メモ | uspto-grants-1985_12 |