Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 638706ノート

反応式

HRID 638706 の反応式
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

生成物 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride収率 77.6%

反応条件

温度
10 °C

実験手順

A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.

後処理

  1. distillationExcess concentrated hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-f28df230f2a842f6bd81173f55feb8ca
出典データセット
uspto-grants-2010_04
特許番号
US07691364B2

反応ノート

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