関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 6-(4-Acetylaminophenoxy)-hexanoic acid methyl ester | HCID 49764491 | — |
| 生成物 | 6-(4-Amino-phenoxy)hexanoic acid hydrochloride | HCID 66811347 | 55.6% |
反応手順
A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07691364B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-aaaf3cd83c2b4643bc5b4bb389e8ae5a |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
