2-Amino-4-methylbenzothiazole → HCID 394241、化合物

反応式

[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([NH2:11])[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.Br[CH2:13][C:14](=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[CH3:1][C:2]1[C:7]2[N:8]3[CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:11]=[C:9]3[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 151322-Amino-4-methylbenzothiazole

HCID 66144Ethyl bromopyruvate

生成物 1

HCID 394241HCID 394241、化合物収率 47.3%

実験手順

Ethyl 5-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared according to the procedure as outlined in Example 1, (Step 1). Starting from 4-methyl-2-amino benzothiazole (8.0 g, 48.7 m.mol) and ethyl bromopyruvate (14.0 g, 71.7 mmol), 6.0 g (45% Yield) of ethyl 5-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was isolated as a brown solid. (M+H) 261.

後処理

customEthyl 5-methylimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared

出典と根拠

ORDレコード: ord-eade180ac1594038a0e35a3eae9dfd02
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07691842B2

反応ノート

読み込み中…

参加物