1,1,1-Trifluoro-2-iodoethane → Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoate

HRID 638948ノート

反応式

HRID 638948 の反応式
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([SH:10])[CH:5]=1.[F:12][C:13]([F:17])([F:16])[CH2:14]I>>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][CH2:14][C:13]([F:17])([F:16])[F:12])[CH:5]=1

参加物

3

反応物 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 4362804Methyl 3-mercaptobenzoate

生成物 1

HCID 68684094Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoate収率 82%

実験手順

3-(2,2,2-Trifluoroethylthio)benzoic acid methyl ester was prepared 3-mercaptobenzoic acid methyl ester and trifluoroethyl iodide by following Method C. The reaction was conducted at room temperature overnight. The crude residue was chromatographed in 10-20% EtOAc/hexanes to afford 3-(2,2,2-trifluoroethylthio)benzoic acid methyl ester (82% yield).

後処理

  1. customThe crude residue was chromatographed in 10-20% EtOAc/hexanes

出典と根拠

ORDレコード
ord-158d5743fcc84cc4883141f7e7f700e3
出典データセット
uspto-grants-2010_04
特許番号
US07691843B2

反応ノート

読み込み中…