Ethyl Acetate → 4-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid

反応式

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12](Br)=[CH:11][C:10]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC[O:23][C:24](C)=[O:25]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:24]([OH:25])=[O:23])=[CH:11][C:10]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 8857Ethyl Acetate

HCID 686865001-(Benzyloxy)-4-bromo-2-(trifluoromethoxy)benzene

生成物 1

HCID 686856714-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid

実験手順

4-Benzyloxy-3-trifluoromethoxybenzoic acid was prepared from 4-benzyloxy-1-bromo-3-trifluoromethoxybenzene by following Method M. The crude product was purified by crystallization using a mixture of EtOAc and hexanes as a solvent (19% yield of desired product from the first crop).

後処理

customThe crude product was purified by crystallization

出典と根拠

ORDレコード: ord-2c293002c18f4882888530ff979cff96
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07691843B2

反応ノート

読み込み中…