Chlorosuccinimide → 3-Chloro-6-methoxyquinolin-4-ol
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[OH:13].[Cl:14]N1C(=O)CCC1=O>C(O)(=O)C>[Cl:14][C:7]1[CH:8]=[N:9][C:10]2[C:5]([C:6]=1[OH:13])=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2参加物
4
反応条件
- 温度
- 60 °C
実験手順
6-Methoxy-quinolin-4-ol (18.5 g) in acetic acid (750 mL) was treated with N-chlorosuccinimide (15.52 g) and the mixture was heated at 60° C. for 4.5 hr, cooled, and evaporated. Excess sodium bicarbonate solution was added and the solid collected and washed with water and dried in vacuo at 40° C. overnight, to give a yellow solid (21.3 g).
後処理
- temperaturecooled
- customevaporated
- additionExcess sodium bicarbonate solution was added
- customthe solid collected
- washwashed with water
- customdried in vacuo at 40° C. overnight
出典と根拠
- ORDレコード
- ord-8e249458ab124e0aa52d6dfbed5d2481
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691850B2
反応ノート
読み込み中…