Diethyl (ethoxymethylene)malonate → Diethyl 2-(((6-methoxypyridin-3-yl)amino)methylene)malonate
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.C(O[CH:13]=[C:14]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])C>CCO>[CH2:18]([O:17][C:15](=[O:16])[C:14](=[CH:13][NH:1][C:2]1[CH:7]=[N:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:19]参加物
4
実験手順
A solution of 5-amino-2-methoxypyridine (Aldrich, 100 g, 0.806 mole) and diethyl ethoxymethylenemalonate (Aldrich, 163 mL, 0.806 mole) in EtOH (1 L) was heated at reflux for 4 h, then was cooled to RT. Concentration to dryness gave the title compound (238 g, quantitative).
後処理
- temperatureat reflux for 4 h
- concentrationConcentration to dryness
出典と根拠
- ORDレコード
- ord-b737f077aa7a41e98f324252e8a9eb0c
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691850B2
反応ノート
読み込み中…