Piperidine → HCID 178467230、化合物

HRID 639161ノート

反応式

HRID 639161 の反応式
[CH3:1][C:2]1[O:6][N:5]=[CH:4][CH:3]=1.C([O-])C.[Na+].[F:11][C:12]([F:26])([F:25])[C:13]1[CH:14]=[C:15]([NH:19][C:20]([CH3:24])=[CH:21][C:22]#[N:23])[CH:16]=[CH:17][CH:18]=1.[CH:27]([C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=1)=O.N1CCCCC1>C(O)C>[C:2]([C:3]1[CH:27]([C:29]2[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=2)[C:21]([C:22]#[N:23])=[C:20]([CH3:24])[N:19]([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([C:12]([F:25])([F:26])[F:11])[CH:14]=2)[C:4]=1[NH2:5])(=[O:6])[CH3:1]

参加物

7

反応物 5

HCID 8082PiperidineHCID 660424-CyanobenzaldehydeHCID 798335-MethylisoxazoleHCID 2723922Sodium ethoxideHCID 50752873-{[3-(Trifluoromethyl)phenyl]amino}but-2-enenitrile

生成物 1

HCID 178467230HCID 178467230、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Under argon, 100 mg (1.20 mmol) 5-methylisoxazole are dissolved in 2 ml ethanol and 81.90 mg (1.20 mmol) sodium ethanolate are added. The mixture is stirred at room temperature for one hour. Then 272.24 mg (1.20 mmol) of the compound of Example 2A, 157.82 mg (1.20 mmol) 4-formylbenzonitrile and 10.25 mg (11.90 μl, 0.12 mmol) piperidine are added to the mixture which is stirred at reflux overnight. After the reaction is finished, the mixture is purified by preparative HPLC.

後処理

  1. stirringis stirred
  2. temperatureat reflux overnight
  3. customthe mixture is purified by preparative HPLC

出典と根拠

ORDレコード
ord-5987c91bd2a2434486cda19897fc2df6
出典データセット
uspto-grants-2010_04
特許番号
US07691854B2

反応ノート

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