Ammonium Hydroxide → Aminopyrazine carboxamide

HRID 639168ノート

反応式

HRID 639168 の反応式
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][CH:8]=[CH:7][N:6]=1)=O.[OH-].[NH4+:13]>>[NH2:11][C:10]1[C:5]([C:3]([NH2:13])=[O:2])=[N:6][CH:7]=[CH:8][N:9]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 72669Methyl 3-aminopyrazinecarboxylate

生成物 1

HCID 280292Aminopyrazine carboxamide

実験手順

A solution of 3-amino-pyrazine-2-carboxylic acid methyl ester (5.0 g, 33 mmol) in concentrated ammonium hydroxide solution (30 mL) was heated at 60° C. for 3 h. The mixture was cooled to RT and the resulting solid filtered. After thoroughly washed with water followed by ether, the title compound was obtained as a brown solid (3.7 g, 82%).

後処理

  1. filtrationthe resulting solid filtered
  2. washAfter thoroughly washed with water

出典と根拠

ORDレコード
ord-13a0c926707542fca425fce8dfe9fd7c
出典データセット
uspto-grants-2010_04
特許番号
US07691858B2

反応ノート

読み込み中…