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Potassium Hydroxide → 6-(4-Fluoro-benzyloxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 4-Fluorobenzylic alcohol | HCID 68022 | — |
| 反応物 | Methyl 6-bromo-5-chloro-2-pyrazinecarboxylate | HCID 59254839 | — |
| 反応物 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68567445 | — |
| 生成物 | 6-(4-Fluoro-benzyloxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68565288 | 13% |
反応手順
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (example 10, step c), the title compound was synthesized from 6-bromo-5-chloro-pyrazine-2-carboxylic acid methyl ester, (4-fluoro-phenyl)-methanol (commercially available), pyrrolidine (commercially available) and subsequent saponification with KOH in 13% yield. m/z (ES+): 318.0 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691863B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-e72cafc6a78b4db198fe2c92a692d0cf |
| 出典メモ | uspto-grants-2010_04 |