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Methyl 2-amino-2-ethylbutanoate → 2-Ethyl-2-[(6-isopropoxy-5-piperidin-1-yl-pyrazine-2-carbonyl)-amino]-butyric acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-amino-2-ethylbutanoate | HCID 13412527 | — |
| 反応物 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 反応物 | 6-Isopropoxy-5-piperidin-1-yl-pyrazine-2-carboxylic acid | HCID 68569451 | — |
| 生成物 | 2-Ethyl-2-[(6-isopropoxy-5-piperidin-1-yl-pyrazine-2-carbonyl)-amino]-butyric acid methyl ester | HCID 24831577 | — |
反応手順
In analogy to the procedure described for the synthesis of 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-Isopropoxy-5-piperidin-1-yl-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 393.3 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691863B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-def4699be341417b849c4ed93ad04cdc |
| 出典メモ | uspto-grants-2010_04 |