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(+)-L-Leucine methyl ester → (S)-4-Methyl-2-{[5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-pentanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+)-L-Leucine methyl ester | HCID 65105 | — |
| 反応物 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 反応物 | 5-Morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid | HCID 68566809 | — |
| 生成物 | (S)-4-Methyl-2-{[5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-pentanoic acid methyl ester | HCID 24831738 | — |
反応手順
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid and (S)-leucine methyl ester (commercially available). m/z (ES+): 435.3 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691863B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-952a504ad21d4fe9b7e4d8226f00887f |
| 出典メモ | uspto-grants-2010_04 |