Hydrochloric Acid → HCID 68569120、化合物
反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[CH:9]=1)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH3:22][N:19]1[CH2:20][CH2:21][CH:16]([CH2:15][O:14][C:10]2[CH:9]=[C:8]([NH2:7])[CH:13]=[CH:12][CH:11]=2)[CH2:17][CH2:18]1参加物
4
実験手順
[3-(1-Methyl-piperidin-4-ylmethoxy)-phenyl]-carbamic acid tert-butyl ester (1.6 g, 0.005 mol) is dissolved in 10 mL of methanol and treated with 10 mL 6 N HCl. The solution is stirred at rt over night and then heated for 4 h to 60° C. The solvent is removed under reduced pressure and the residue dried under vacuum to give a tan foam which is used without further purification. HPLC: 8.20 (System X2); [M+H]+ 221.0.
後処理
- temperatureheated for 4 h to 60° C
- customThe solvent is removed under reduced pressure
- customthe residue dried under vacuum
- customto give a tan foam which
- customis used without further purification
出典と根拠
- ORDレコード
- ord-55bc32298d21445d9b37a2dda745eb4c
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691855B2
反応ノート
読み込み中…