4-Trifluoromethyl-1,2-phenylenediamine → HCID 178455650、化合物
反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[N:3]=1.[C:16]([S:20]([NH:23][C@@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](O)=O)[CH2:26][CH2:25]1)(=[O:22])=[O:21])([CH3:19])([CH3:18])[CH3:17].N[C@@H]1CC[C@H](C(O)=O)CC1.FC(F)(F)C1C=CC(N)=C(N)C=1>>[C:16]([S:20]([NH:23][C@@H:24]1[CH2:25][CH2:26][C@H:27]([C:30]2[NH:8][C:7]3[C:2](=[N:3][C:4]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[F:15])=[N:5][CH:6]=3)[N:1]=2)[CH2:28][CH2:29]1)(=[O:22])=[O:21])([CH3:19])([CH3:17])[CH3:18]参加物
5
実験手順
By following the same procedure as described in Example 1 except that use was made of 4,5-diamino-2-(2-florophenyl)-pyrimidine and cis-4-tert-butylsulfonylaminocyclohexane-carboxylic acid as prepared from cis-4-aminocyclohexane-carboxylic acid in accordance with the 1st, 2nd and 4th steps of Example 4 described in WO0137826 in place of 4-trifluoromethyl-1,2-phenylenediamine, the title compound was prepared.