(2-Benzylamino-3-nitro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid ethyl ester → (3-Amino-2-benzylamino-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester

HRID 639631ノート

反応式

HRID 639631 の反応式
[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:9]=[C:8]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:7]=1[N+:24]([O-])=O)[CH3:2].[H][H]>C(O)C.[Ni]>[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:9]=[C:8]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:7]=1[NH2:24])[CH3:2]

参加物

5

反応物 2

HCID 67456211(2-Benzylamino-3-nitro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 67455304(3-Amino-2-benzylamino-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester収率 99.3%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

(2-benzylamino-3-nitro-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester (95 mg, 0.25 mmol) was dissolved in 10 mL of ethanol and Raney Nickel (20 mg, 20% MW) was added then the reaction mixture was stirred at room temperature in a bomb under 50 PSI of hydrogen for 2 h. The mixture was filtered through arbocel and the filtrate was concentrated in vacuo to give 88 mg of the title compound as a pale green gum.

後処理

  1. filtrationThe mixture was filtered through arbocel
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-b8ecb760d2624a199279fc1a2051ad43
出典データセット
uspto-grants-2010_04
特許番号
US07691877B2

反応ノート

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