4-Methoxymethyl-oxazole → [2-Amino-6-(4-methoxymethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-benzyl-carbamic acid ethyl ester

HRID 639663ノート

反応式

HRID 639663 の反応式
[CH3:1][O:2][CH2:3][C:4]1[N:5]=[CH:6][O:7][CH:8]=1.[CH2:9]([O:11][C:12](=[O:32])[N:13]([C:21]1[CH:26]=[C:25](Br)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:10]>[Cl-].[Cl-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Pd+2]>[CH2:9]([O:11][C:12](=[O:32])[N:13]([C:21]1[CH:26]=[C:25]([C:6]2[O:7][CH:8]=[C:4]([CH2:3][O:2][CH3:1])[N:5]=2)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH3:10]

参加物

4

反応物 2

HCID 230809034-Methoxymethyl-oxazoleHCID 86614485(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester

生成物 1

HCID 67457819[2-Amino-6-(4-methoxymethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-benzyl-carbamic acid ethyl ester

試薬・触媒・溶媒 1

HCID 84124Bis(triphenylphosphine)palladium chloride触媒

実験手順

The title compound was prepared following the example in preparation 70, using 4-methoxymethyl-oxazole (114 mg), (2-amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester (200 mg) and palladium bis(triphenylphosphine)dichloride (71 mg), giving the product (160 mg) as a yellow gum.

後処理

  1. customin preparation 70

出典と根拠

ORDレコード
ord-9bb8e7136ad849a7b3f8ab148303d77e
出典データセット
uspto-grants-2010_04
特許番号
US07691877B2

反応ノート

読み込み中…