(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol → 4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639795ノート

反応式

HRID 639795 の反応式
[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH2:14][OH:15])[CH3:2]>[O-2].[O-2].[Mn+4].ClCCl>[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH:14]=[O:15])[CH3:2]

参加物

4

反応物 1

HCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol

生成物 1

HCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Dichloromethane (4 mL) was added to a vial containing (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (56.7 mg, 0.279 mmol) and manganese dioxide (364.3 mg, 4.19 mmol) was added. The vial was sealed and the reaction was allowed to stir for two hours. The reaction was filtered through celite and concentrated to yield the title compound. 1H NMR (CDCl3) δ (ppm): 10.21 (s, 1H), 8.88 (d, 2H), 7.63 (d, 2H), 4.45 (q, 2H), 1.48 (t, 3H).

後処理

  1. additionwas added
  2. customThe vial was sealed
  3. filtrationThe reaction was filtered through celite and
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a3d56a31fdad4b38b1c27b576c108d9a
出典データセット
uspto-grants-2010_04
特許番号
US07691892B2

反応ノート

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