Hydrochloric Acid → HCID 68547925、化合物

HRID 639859ノート

反応式

HRID 639859 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 24802847HCID 24802847、化合物

生成物 1

HCID 68547925HCID 68547925、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

(1S,6R)-6-(3,4-dichlorophenyl)-3-methyl-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E12, 16 mg) was treated with hydrochloric acid 1.0M in diethyl ether (0.064 mL). 0.5 mL of diethyl ether were added and a colourless solid formed. Organic phase was removed after decantation of the solid. Colourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg).

後処理

  1. customa colourless solid formed
  2. customOrganic phase was removed after decantation of the solid
  3. customColourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg)

出典と根拠

ORDレコード
ord-77dbcab9c8b4481aaacbf804ba142cb9
出典データセット
uspto-grants-2010_04
特許番号
US07691893B2

反応ノート

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