(+)-Solketal → 1-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-methoxy4-phenylisoquinoline-3-carbonitrile

反応式

[CH2:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:7]([C:23]#[N:24])[N:6]=1)[CH:2]=[CH2:3].[CH3:25][C:26]1([CH3:33])[O:30][C@@H](CO)C[O:27]1>>[CH3:25][C:26]1([CH3:33])[O:30][C@@H:2]([CH2:1][O:4][C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=3)[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:7]([C:23]#[N:24])[N:6]=2)[CH2:3][O:27]1

参加物

反応物 2

HCID 736057(+)-Solketal

HCID 114384741-(Allyloxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile

生成物 1

HCID 112230231-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-methoxy4-phenylisoquinoline-3-carbonitrile

実験手順

Following the procedure for 1-(allyloxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using (S)-(+)-2,2,-dimethyl-1,3-dioxolane-4-methanol in place of allyl alcohol, the title compound was synthesized.

出典と根拠

ORDレコード: ord-e28f8204f93748c387fc541aaa1e507e
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07691879B2

反応ノート

読み込み中…