(R)-3-Pyrrolidinol → 1-[(3R)-3-hydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile

反応式

C(N[C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:7]([C:23]#[N:24])[N:6]=1)C=C.[NH:25]1[CH2:29][CH2:28][C@@H:27]([OH:30])[CH2:26]1>>[OH:30][C@@H:27]1[CH2:28][CH2:29][N:25]([C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=3)[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:7]([C:23]#[N:24])[N:6]=2)[CH2:26]1

参加物

反応物 2

HCID 2759337(R)-3-Pyrrolidinol

HCID 11358963(Allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile

生成物 1

HCID 117723441-[(3R)-3-hydroxypyrrolidin-1-yl]-6-methoxy-4-phenylisoquinoline-3-carbonitrile

実験手順

Following the procedure for 1-(allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using (R)-3-pyrrolidinol in place of allylamine, the title compound was synthesized.

出典と根拠

ORDレコード: ord-02996eab839f4cb0adfffb863ebf756f
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07691879B2

反応ノート

読み込み中…