化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 2-Hydroxy-4-methoxybenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-Methoxysalicylic Acid | HCID 75231 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Hydroxy-4-methoxybenzoyl chloride | HCID 23118559 | — |
反応手順
To a solution of 2-hydroxy-4-methoxybenzoic acid (20 g, 118.9 mmol) in 500 mL CH2Cl2 was added thionyl chloride (21.2 g, 178.4 mmol), followed by 0.4 mL DMF. After stirring at rt for 8 h, the reaction mixture was concentrated to a white solid (azeotroped twice from benzene). This material was used as is in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691879B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-ecf2ec74ab534a90a544406e79f18c91 |
| 出典メモ | uspto-grants-2010_04 |