Potassium Carbonate → 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxamide

HRID 639972ノート

反応式

HRID 639972 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)=[O:4].[N+:13]([C:16]1[C:17]([C:21]([NH2:23])=[O:22])=[N:18][NH:19][CH:20]=1)([O-:15])=[O:14].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:12][C:8]1[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:19]2[CH:20]=[C:16]([N+:13]([O-:15])=[O:14])[C:17]([C:21]([NH2:23])=[O:22])=[N:18]2)[CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 23889312-chloro-N-(3-fluorophenyl)acetamideHCID 178513854HCID 178513854、化合物

生成物 1

HCID 686400711-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxamide収率 69%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-chloro-N-(3-fluorophenyl)acetamide (0.65 g, 3.46 mmol), 4-nitro-1H-pyrazole-3-carboxamide (0.54 g, 3.46 mmol) and potassium carbonate (0.57 g, 4.13 mmol) in dimethylformamide (10 ml) was stirred at room temperature for 48 hours. The mixture was evaporated and the residue partitioned between ethyl acetate and water. The organic phase was separated, washed, dried and then concentrated to yield 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxamide (730 mg, 69% yield).

後処理

  1. customThe mixture was evaporated
  2. customthe residue partitioned between ethyl acetate and water
  3. customThe organic phase was separated
  4. washwashed
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-63d60955f06141bf81f005c351f3162d
出典データセット
uspto-grants-2010_04
特許番号
US07691867B2

反応ノート

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