Potassium Carbonate → 2-[3-(acetylamino)-4-nitro-1H-pyrazol-1-yl]-N-(3-fluorophenyl)acetamide

HRID 639977ノート

反応式

HRID 639977 の反応式
[N+:1]([C:4]1[C:5]([NH:9][C:10](=[O:12])[CH3:11])=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].Cl[CH2:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=1)=[O:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:10]([NH:9][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:8][N:7]([CH2:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)=[O:16])[N:6]=1)(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 23889312-chloro-N-(3-fluorophenyl)acetamideHCID 178474501HCID 178474501、化合物

生成物 1

HCID 686398472-[3-(acetylamino)-4-nitro-1H-pyrazol-1-yl]-N-(3-fluorophenyl)acetamide収率 55%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

A mixture of N-(4-nitro-1H-pyrazol-3-yl)acetamide (0.380 g, 2.25 mmol), 2-chloro-N-(3-fluorophenyl)acetamide (0.420 g, 2.25 mmol) and potassium carbonate (00.370 g, 2.7 mmol) in dimethyl formamide (10 ml) was heated at 50° C. for 1 hour. The mixture was filtered and the filtrate was evaporated. The residue was triturated with a mixture of 2% methanol in dichloromethane and then with diethyl ether to give 2-[3-(acetylamino)-4-nitro-1H-pyrazol-1-yl]-N-(3-fluorophenyl)acetamide

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was triturated with a mixture of 2% methanol in dichloromethane

出典と根拠

ORDレコード
ord-44c5b635ffc045d0b7dcd093a1747cde
出典データセット
uspto-grants-2010_04
特許番号
US07691867B2

反応ノート

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